Ex-SASP-erating cancer

SIN3B, the SASP, and pancreatic cancer

Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study.

SASP reflects senescence

erating Interactive Explanations

Existing approaches to text generation fail to consider how interactions with the user may be managed within a coherent explanation or description. This paper presents an approach to generating such interactive explanations based on two levels of discourse planning content planning and dialogue planning. The system developed allows aspects of the changing context to be monitored with an explana...

TOLL-erating cardiac hypertrophy following pressure overload.

Sensing and defeating microbial infections are essential to the survival of metazoan species and contingent upon the reliable detection of pathogens, which are characterized by rapid evolution and molecular heterogeneity. Multicellular species have developed two overall strategies to kill and remove parasites, to send them ‘‘floating on the Stygian river’’ (after the river Styx in Hades, the un...

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

Endothelial cell senescence is characterized by acquisition of senescence-associated secretory phenotype (SASP), able to promote inflammaging and cancer progression. Emerging evidence suggest that preventing SASP development could help to slow the rate of aging and the progression of age-related diseases, including cancer. Aim of this study was to evaluate whether and how adalimumab, a monoclon...